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P., Gautam-Basak, M

found that CBP (cAMP-responsive element-binding (CREB)-binding protein) and SIRT4 in PDAC cells bind the K44 site of BCAT2 to acetylate this site, which further promotes the degradation of BCAT2 through the ubiquitin-protein pathway, reduces the metabolic rate of BCAAs in PDAC, and, in turn, inhibits the growth of tumor cells

This is exemplified by the initiation of clinical trials with human embryonic stem cell (hESC) derived retinal pigmented epithelium 14,15

doi: 10.1038/s41598-017-18639-6 49 XieJShultsKFlyeLJiangFHeadDRBriggsRC

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